Pathology, Molecular Pathology and CWS Biobanking

Soft tissue sarcomas (STS) include a variety of histological and molecular different rare malignant tumors. They display a wide range of differentiation towards mesenchymal lineages including muscle, adipose and other connective tissues. Genetically STS can be subdivided into two different main groups: tumors characterized by specific translocations, the drivers of tumor pathogenesis that can be used as precise diagnostic markers, and tumors that display complex caryotypes and chromosomal instability.

The correct histopathological and molecular classification of STS is crucial for an adequate treatment of patients, to establish a new risk stratification and to develop new treatment strategies for the future.

The basis of molecular diagnostics and further molecular characterization is the asservation of high quality sample material (tumor tissue and liquid sample material) by cryoconservation from all registered patients in addition to FFPE materials.

We recommend to send

1. FFPE material (mandatory for all patients registered in SoTiSaR/ 2.0 to Prof. C. Vokuhl, Bonn, for reference pathology
2. Cryoconserved tissue and liquid samples collected in the CWS Biobank Stuttgart/ SoTiSaR 2.0-BIO for reference molecular diagnostics and for research projects.

Details on handling tumor and liquid samples for reference diagnostics and biobanking/ research projects are available on request and in the „members area“.