Wissenschaft und Lehre

Bielack S, Fox CP, Hoang-Xuan K, Giró-Perafita A, Rizzari C.
A Delphi study to determine the epidemiology and clinical management of patients treated with HDMTX who develop methotrexate (MTX) delayed elimination in France, Germany, Italy, and the UK.
Health Sci Rep. 2024 Jan 5;7(1):e1749. doi: 10.1002/hsr2.1749. 2024 Publication Link

Mettmann VL, Blattmann C, Friedel G, Harrabi S, von Kalle T, Kager L, Kevric M, Kühne T, Nathrath M, Sorg B, Werner M, Bielack SS, Hecker-Nolting S.
Primary Multi-Systemic Metastases in Osteosarcoma: Presentation, Treatment, and Survival of 83 Patients of the Cooperative Osteosarcoma Study Group.
Cancers (Basel). 2024 Jan 8;16(2):275. doi: 10.3390/cancers16020275 2024 Publication Link

Scobioala S, Parfitt R, Matulat P, Byrne J, Langer T, Troschel FM, Hesping AE, Clemens E, Kaatsch P, Grabow D, Kaiser M, Spix C, Kremer LC, Calaminus G, Baust K, Kuehni CE, Weiss A, Strebel S, Kuonen R, Elsner S, Haupt R, Garré ML, Gruhn B, Kepak T, Kepakova K, Winther JF, Kenborg L, Rechnitzer C, Hasle H, Kruseova J, Luks A, Lackner H, Bielack S, Beck JD, Jürgens H, van den Heuvel-Eibrink MM, Zolk O, Eich HT, Am Zehnhoff-Dinnesen A; PanCareLIFE Consortium.
The impact of the temporal sequence of cranial radiotherapy and platin-based chemotherapy on hearing impairment in pediatric and adolescent CNS and head-and-neck cancer patients: A report from the PanCareLIFE consortium.
Int J Cancer. 2024 Jan 15;154(2):320-331. doi: 10.1002/ijc.34732. 2024 Publication Link

Eichholz T, Döring M, Giardino S, Gruhn B, Seitz C, Flaadt T, Schwinger W, Ebinger M, Holzer U, Mezger M, Teltschik HM, Sparber-Sauer M, Koscielniak E, Abele M, Handgretinger R, Lang P.
"Haploidentical hematopoietic stem cell transplantation as individual treatment option in pediatric patients with very high-risk sarcomas. "
"Front Oncol. 2023 Feb 21;13:1064190. doi: 10.3389/fonc.2023.1064190. eCollection 2023. PMID: 36895486" 2023

Sparber-Sauer M, Dietzschold M, Schönstein A, Heinz A, Vokuhl C, Pajtler KW, Harrabi S, Lin YL, Kalle TV, Hagen R, Ladenstein R, Kazanowska B, Ljungman G, Klingebiel T, Ebinger M, Koscielniak E, Münter M, Timmermann B; CWS Study Group.
"Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma: Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry. "
"Pediatr Blood Cancer. 2024 Jan;71(1):e30742. doi: 10.1002/pbc.30742. Epub 2023 Oct 25. PMID: 37880926" 2023

Heinz AT, Schönstein A, Ebinger M, Fuchs J, Timmermann B, Seitz G, Vokuhl C, Münter M, Pajtler KW, Stegmaier S, von Kalle T, Kratz CP, Ljungman G, Juntti H, Klingebiel T, Koscielniak E, Sparber-Sauer M; Cooperative Weichteilsarkom Studiengruppe.
"Significance of fusion status, Oberlin risk factors, local and maintenance treatment in pediatric and adolescent patients with metastatic rhabdomyosarcoma: Data of the European Soft Tissue Sarcoma Registry SoTiSaR. "
"Pediatr Blood Cancer. 2024 Jan;71(1):e30707. doi: 10.1002/pbc.30707. Epub 2023 Oct 9. PMID: 37814424" 2023

Trama A, Stark D, Bozovic-Spasojevic I, Gaspar N, Peccatori F, Toss A, Bernasconi A, Quarello P, Scheinemann K, Jezdic S, Blondeel A, Mountzios G, Bielack S, Saloustros E, Ferrari A.
Cancer burden in adolescents and young adults in Europe.
ESMO Open. 2023 Feb;8(1):100744. doi: 10.1016/j.esmoop.2022.100744 2023 Publication Link

Sparber-Sauer M, Corradini N, Affinita MC, Milano GM, Pierron G, Carton M, Tirode F, Pissaloux D, Alaggio R, Vokuhl C, Bisogno G, Berlanga P, Ferrari A, Orbach D.
Clinical characteristics and outcomes for children, adolescents and young adults with "CIC-fused" or "BCOR-rearranged" soft tissue sarcomas: A multi-institutional European retrospective analysis
"Cancer Med. 2023 Jul;12(13):14346-14359. doi: 10.1002/cam4.6113. Epub 2023 May 22. PMID: 37212486" 2023

Kolodziejczak AS, Guerrini-Rousseau L, Planchon JM, Ecker J, Selt F, Mynarek M, Obrecht D, Sill M, Autry RJ, Stutheit-Zhao E, Hirsch S, Amouyal E, Dufour C, Ayrault O, Torrejon J, Waszak SM, Ramaswamy V, Pentikainen V, Demir HA, Clifford SC, Schwalbe EC, Massimi L, Snuderl M, Galbraith K, Karajannis MA, Hill K, Li BK, Walsh M, White CL, Redmond S, Loizos L, Jakob M, Kordes UR, Schmid I, Hauer J, Blattmann C, Filippidou M, Piccolo G, Scheurlen W, Farrag A, Grund K, Sutter C, Pietsch T, Frank S, Schewe DM, Malkin D, Ben-Arush M, Sehested A, Wong TT, Wu KS, Liu YL, Carceller F, Mueller S, Stoller S, Taylor MD, Tabori U, Bouffet E, Kool M, Sahm F, von Deimling A, Korshunov A, von Hoff K, Kratz CP, Sturm D, Jones DTW, Rutkowski S, van Tilburg CM, Witt O, Bougeard G, Pajtler KW, Pfister SM, Bourdeaut F, Milde T
Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome.
Neuro Oncol. 2023 Dec 8;25(12):2273-2286. 2023

Das A, Fernandez NR, Levine A, Bianchi V, Stengs LK, Chung J, Negm L, Dimayacyac JR, Chang Y, Nobre L, Ercan AB, Sanchez-Ramirez S, Sudhaman S, Edwards M, Larouche V, Samuel D, Van Damme A, Gass D, Ziegler DS, Bielack SS, Koschmann C, Zelcer S, Yalon-Oren M, Campino GA, Sarosiek T, Nichols KE, Loret De Mola R, Bielamowicz K, Sabel M, Frojd CA, Wood MD, Glover JM, Lee YY, Vanan M, Adamski JK, Perreault S, Chamdine O, Hjort MA, Zapotocky M, Carceller F, Wright E, Fedorakova I, Lossos A, Tanaka R, Osborn M, Blumenthal DT, Aronson M, Bartels U, Huang A, Ramaswamy V, Malkin D, Shlien A, Villani A, Dirks PB, Pugh TJ, Getz G, Maruvka YE, Tsang DS, Ertl-Wagner B, Hawkins C, Bouffet E, Morgenstern DA, Tabori U.
Combined immunotherapy improves outcome for replication repair deficient (RRD) high-grade glioma failing anti-PD1 monotherapy: A report from the International RRD Consortium.
Cancer Discov. 2023 Oct 12. doi: 10.1158/2159-8290. 2023 Publication Link

Bielack SS, Kager L, Kühne T, Langer T, Reichardt P, Blattmann C, Kevric M, Mettmann V, Sorg B, Hecker-Nolting S.
Establishment, Maintenance, and Performance of the Cooperative Osteosarcoma Study Group (COSS).
Cancers (Basel). 2023 Feb 28;15(5):1520. doi: 10.3390/cancers15051520. 2023 Publication Link

van Ewijk R, Herold N, Baecklund F, Baumhoer D, Boye K, Gaspar N, Harrabi SB, Haveman LM, Hecker-Nolting S, Hiemcke-Jiwa L, Martin V, Fernandez CM, Palmerini E, van de Sande MAJ, Strauss SJ, Bielack SS, Kager L.
European standard clinical practice recommendations for children and adolescents with primary and recurrent osteosarcoma
EJC Paediatr Oncol 2 (2023) 100029 2023 Publication Link

Maennlin S, Chaika M, Gassenmaier S, Grimm R, Sparber-Sauer M, Fuchs J, Schmidt A, Ebinger M, Hettmer S, Gatidids S, Dittmann H, Schäfer JF.
Evaluation of functional and metabolic tumor volume using voxel-wise analysis in childhood rhabdomyosarcoma
"Pediatr Radiol. 2023 Mar;53(3):438-449. doi: 10.1007/s00247-022-05540-2. Epub 2022 Nov 18. PMID: 36399161" 2023

" Orbach D, Sparber-Sauer M, Corradini N, Ferrari A, Owens C, Casanova M."
Infantile fibrosarcoma: Is spontaneous regression possible?
"Pediatr Blood Cancer. 2023 Nov;70(11):e30623. doi: 10.1002/pbc.30623. Epub 2023 Aug 14. PMID: 37580894" 2023

Schoot RA, Orbach D, Minard Colin V, Alaggio R, Di Carlo D, Corradini N, Mercolini F, Milano GM, van Noesel MM, Rome A, Dall'Igna P, Pajtler K, Sparber-Sauer M, Ferrari A, Casanova M.
Inflammatory Myofibroblastic Tumor With ROS1 Gene Fusions in Children and Young Adolescents.
"JCO Precis Oncol. 2023 Sep;7:e2300323. doi: 10.1200/PO.23.00323. PMID: 37856763" 2023

Schoot RA, van Ewijk R, von Witzleben AA, Kao SC, Merks JHMH, Morosi C, Pace E, Shulkin BL, Ferrari A, von Kalle T, van Rijn RR, Weiss AR, Sparber-Sauer M, Ter Horst SAJ, McCarville MB.
INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) consensus statement: Imaging recommendations for the management of rhabdomyosarcoma.
"Eur J Radiol. 2023 Sep;166:111012. doi: 10.1016/j.ejrad.2023.111012. Epub 2023 Jul 25. PMID: 37541182" 2023

Lautz TB, Martelli H, Fuchs J, Chargari C, Smeulders N, Granberg CF, Wolden SL, Sparber-Sauer M, Hawkins DS, Bisogno G, Koscielniak E, Rodeberg DA, Seitz G; INSTRuCT group.
Local treatment of rhabdomyosarcoma of the female genital tract: Expert consensus from the Children's Oncology Group, the European Soft-Tissue Sarcoma Group, and the Cooperative Weichteilsarkom Studiengruppe.
"Pediatr Blood Cancer. 2023 May;70(5):e28601. doi: 10.1002/pbc.28601. Epub 2020 Aug 6. PMID: 32762004 " 2023

Gotta J, Bochennek K, Klingebiel T, Bielack S, Wild PJ, Demes MC, Gradhand E.
Metachronous Osteosarcoma, A Differential Diagnosis to be Considered in Children With Osteosarcoma: A Review of Literature and a Case From Our Center.
J Pediatr Hematol Oncol. 2023 Apr 1;45(3):105-110. doi: 10.1097/MPH.0000000000002560. 2023 Publication Link

Dhaenens BAE, Mahler F, Batchelor H, Dicks P, Gaillard S, Nafria B, Kopp-Schneider A, Ribeiro MA, Schwab M, Sparber-Sauer M, Leubner J, de Wildt SN, Oostenbrink R.
Optimizing expert and patient input in pediatric trial design: Lessons learned and recommendations from a collaboration between conect4children and European Patient-CEntric ClinicAl TRial PLatforms.
"Clin Transl Sci. 2023 Aug;16(8):1458-1468. doi: 10.1111/cts.13547. Epub 2023 Jun 30. PMID: 37391924" 2023

Bielack SS, Blattmann C, Hassenpflug W, Kager L, Kuhne T, Kevric M, Schlegel PG, Mettmann V, Sorg B, Hecker-Nolting S.
Osteosarcoma Arising After Ewing Sarcoma or Vice Versa: A Report of 20 Affected Patients from the Cooperative Osteosarcoma Study Group (COSS).
Anticancer Res. 2023 Nov;43(11):4975-4981. doi: 10.21873/anticanres.16696. 2023 Publication Link

Hecker-Nolting S, Baumhoer D, Blattmann C, Kager L, Kühne T, Kevric M, Lang S, Mettmann V, Sorg B, Werner M, Bielack SS.
Osteosarcoma pre-diagnosed as another tumor: a report from the Cooperative Osteosarcoma Study Group (COSS).
J Cancer Res Clin Oncol. 2023 May;149(5):1961-1967. doi: 10.1007/s00432-022-04156-1. 2023 Publication Link

Bielack SS, Lindner LH, Egerer G, Benzler K, Blattmann C, Grube M, Hahn D, Kager L, Kühne T, Mettmann V, Reichardt P, Hecker-Nolting S.
Osteosarcomas in older adults: A report from the Cooperative Osteosarcoma Study Group.
J Geriatr Oncol. 2023 Apr;14(3):101445. doi: 10.1016/j.jgo.2023.101445. 2023 Publication Link

Palmerini E, Reichardt P, Hall KS, Bertulli R, Bielack SS, Comandone A, Egerer G, Hansmeier A, Kevric M, Carretta E, Hansson L, Jebsen N, Eriksson M, Bruland ØS, Donati DM, Ibrahim T, Smeland S, Ferrari S.
Outcome of rare primary malignant bone sarcoma treated with multimodal therapy: Results from the EUROpean Bone Over 40 Sarcoma Study (EURO-B.O.S.S.).
Cancer. 2023 Nov 15;129(22):3564-3573. doi: 10.1002/cncr.34964. 2023 Publication Link

Tramsen L, Bochennek K, Sparber-Sauer M, Salzmann-Manrique E, Scheer M, Dantonello T, Borkhardt A, Dirksen U, Thorwarth A, Greiner J, Ebinger M, Weclawek-Tompol J, Ladenstein R, Ljungman G, Hallmen E, Lehrnbecher T, Koscielniak E, Klingebiel T.
Pediatric Patients with Stage IV Rhabdomyosarcoma Significantly Benefit from Long-Term Maintenance Therapy: Results of the CWS-IV 2002 and the CWS DOK IV 2004-Trials.
"Cancers (Basel). 2023 Mar 30;15(7):2050. doi: 10.3390/cancers15072050. PMID: 37046711 " 2023

Bodmer N, Hecker-Nolting S, Friedel G, Blattmann C, Kager L, Kessler T, Kevric M, Kühne T, Mettmann V, Müller-Abt P, Sorg B, Theobald M, Bielack SS.
Primary osteosarcoma of the ribs: A report from the Cooperative Osteosarcoma Study Group.
Cancer. 2023 Jun 15;129(12):1895-1903. doi: 10.1002/cncr.34744. 2023 Publication Link

Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, Kotz R, Salzer-Kuntschik M, Werner M, Winkelmann W, Zoubek A, Jürgens H, Winkler K.
Prognostic Factors in High-Grade Osteosarcoma of theExtremities or Trunk: An Analysis of 1,702 Patients Treatedon Neoadjuvant Cooperative Osteosarcoma Study GroupProtocols.
J Clin Oncol. 2023 Sep 20;41(27):4323-4337. doi: 10.1200/JCO.22.02767. 2023 Publication Link

Heinz AT, Ebinger M, Schönstein A, Fuchs J, Timmermann B, Seitz G, Vokuhl C, Münter MW, Pajtler KW, Stegmaier S, von Kalle T, Kratz CP, Rößler J, Ljungman G, Klingebiel T, Koscielniak E, Sparber-Sauer M; Cooperative Weichteilsarkom Studiengruppe (CWS).
Second-line treatment of pediatric patients with relapsed rhabdomyosarcoma adapted to initial risk stratification: Data of the European Soft Tissue Sarcoma Registry (SoTiSaR).
"Pediatr Blood Cancer. 2023 Jul;70(7):e30363. doi: 10.1002/pbc.30363. Epub 2023 Apr 17. PMID: 37066598" 2023

Mettmann VL, Baumhoer D, Bielack SS, Blattmann C, Friedel G, von Kalle T, Kager L, Kevric M, Nathrath M, Sorg B, Dürken M, Hecker-Nolting S
Solitary pulmonary metastases at first recurrence of osteosarcoma: Presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group.
Cancer Med. 2023 Sep;12(17):18219-18234. 2023

Bielack SS, Palmerini E
Stand with Ukraine
Pediatr Blood Cancer. 2023;e30301. doi: 10.1002/pbc.30301 2023 DOI Link

Bielack SS, Reichardt P, Lindner LH, Hecker-Nolting S
Systemische Therapie von Osteosarkomen
InFo Hämatologie + Onkologie 2023; 26 (3). doi: - 2023

Sparber-Sauer M, Ferrari A, Spunt SL, Vokuhl C, Casey D, Lautz TB, Meyer WH, Walterhouse DO, Pajtler KW, Alaggio R, Schmidt A, Safwat A, Timmermann B, Dall'Igna P, Chen S, Weiss AR, Orbach D.
The significance of margins in pediatric Non-Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)
"Cancer Med. 2023 May;12(10):11719-11730. doi: 10.1002/cam4.5671. Epub 2023 Feb 6. PMID: 36744538" 2023

Hecker-Nolting S, Kager L, Kühne T, Baumhoer D, Blattmann C, Friedel G, von Kalle T, Kevric M, Mayer-Steinacker R, Schwarz R, Sorg B, Wirth T, Bielack SS.
Ultra-Late Osteosarcoma Recurrences: An Analysis of 17 Cooperative Osteosarcoma Study Group Patients with a First Recurrence Detected More Than 10 Years After Primary Tumor Diagnosis.
J Adolesc Young Adult Oncol. 2023 Feb;12(1):76-82. doi: 10.1089/jayao.2021.0221. 2023 Publication Link